By Doyen T. Nguyen
Circulate cytometry immunophenotyping of hematopoietic issues is a posh and important workout that calls for an excellent figuring out of mobilephone lineages, developmental pathways, and physiological adjustments, in addition to huge event in hematopathology. the method comprises a number of interrelated phases, from the preliminary clinical choice concerning which hematologic c- dition is suitable for FCM assay, to the ultimate step of analysis wherein the FCM information is correlated with different proper scientific and laboratory info. the particular FCM checking out comprises 3 significant steps: pre-analytical (specimen processing, antibody staining), analytical (acquiring information at the stream cytometer) and post-analytical (data research and interpretation). The literature, together with the most recent FCM textbooks, presents abundant info at the te- nical ideas of FCM reminiscent of instrumentation, reagents and laboratory tools, in addition to quality controls and caliber coverage. equally, correlations of morphologic findings and p- notypic profiles were good coated in lots of courses. by contrast, less recognition has been given to the opposite both very important facets of FCM immunophenotyping, in particular info research. The latter is a vital step during which a phenotypic profile is confirmed. To bridge this hole within the literature, the focal point of this ebook is extra on FCM info research than laboratory equipment and technical information. For the reader to get to grips with our information research process, an outline of our method of the pre-analytical and analytical steps can also be provided, with an emphasis at the pre-analytical points, that have been not often touched upon within the literature.
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