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Download E-books Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena PDF

By Masood N. Khan, John W. Findlay

A consolidated and entire reference on ligand-binding assays

Ligand-binding assays (LBAs) stand because the cornerstone of aid for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, a space of burgeoning curiosity within the pharmaceutical undefined. but, outdoor of the Crystal urban convention complaints, little tips has been on hand for LBA validation, rather for assays used to aid macromolecule drug improvement. Ligand-Binding Assays: improvement, Validation, and Implementation within the Drug improvement Arena solutions that transforming into want, serving as a reference textual content discussing serious features of the advance, validation, and implementation of ligand-binding assays within the drug improvement field.

Ligand-Binding Assays covers crucial issues concerning ligand-binding assays, from pharmacokinetic reports, the advance of LBAs, assay validation, statistical LBA features, and regulatory points, to software program for LBAs and robotics and different rising methodologies for LBAs. Highlights include:

  • A common dialogue of demanding situations and confirmed techniques within the improvement of ligand-binding assays

  • More exact exam of features of those assays while utilized to aid of pharmacokinetic and toxicokinetic experiences of compounds at diverse levels within the discovery or improvement timeline

  • A concise, yet precise, dialogue of validation of ligand-binding assays for macromolecules

  • A useful method of "fit-for-purpose" validation of assays for biomarkers, these molecules receiving elevated realization as in all probability demonstrating that the objective selected in discovery is being modulated through the candidate healing, either in nonclinical and medical studies

Written by way of a group of world-recognized experts within the box, Ligand-Binding Assays presents key details to a extensive diversity of practitioners, either within the pharmaceutical and allied industries and in similar agreement examine agencies and educational laboratories and, might be, even within the box of diagnostics and medical chemistry.

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