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Download E-books Receptor - Based Drug Design (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs) PDF

By Paul Leff

Making use of a variety of examples from G-protein-coupled receptors and ligand-gated ion channels, this particular, single-source reference illustrates the rules of pharmacological research and receptor category which are the root of rational drug layout. Explains the experimental and theoretical equipment used to symbolize interactions among ligands and receptors-providing the pharmacological info had to resolve therapy difficulties and facilitate the drug layout approach! Demonstrating the achievements of the receptor-based process in therapeutics and indicating destiny instructions, Receptor-Based Drug layout ·introduces novel computer-assisted innovations for the layout of latest agonists, antagonists, and inverse agonists for G-protein-coupled receptors ·shows how you can check agonist concentration-effect curve information ·discusses radioligand binding assays ·presents new in vitro multiarray assays for G-protein-coupled receptors ·explains using person moment messenger signaling responses in examining drug-receptor interactions ·examines the position of electrophysiology find new medications and drug ambitions ·describes selectively appearing b-adrenoceptor agonists and glucocorticoid steroids for bronchial asthma therapy ·outlines the explanation for utilizing angiotensin receptor antagonists ·and extra! Written by means of over 25 foreign professionals and containing approximately 1200 bibliographic citations, Receptor-Based Drug layout is a pragmatic source for pharmacologists, pharmacists, and pharmaceutical scientists; natural and medicinal chemists and biochemists; molecular biologists; biomedical researchers; and upper-level undergraduate and graduate scholars in those disciplines.

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