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By Jerry M. Collins (auth.), D. G. Poplack, L. Massimo, P. Cornaglia-Ferraris (eds.)

The dramatic development made lately within the remedy of kid­ hood malignancies has been largely the results of advances within the box of pharmacology. Chemotherapy is the main healing modality used to regard adolescence melanoma. Rational management of antineoplastic chemo­ remedy to the kid with melanoma calls for the pediatric oncologist to have an intensive figuring out of the basic rules of scientific pharmaco­ logy, an intimate wisdom of the explicit brokers getting used, and an conscious­ ness of the original biologic and physiologic gains of youngsters. In mid 1985, a exclusive crew of pediatric oncologists and scientific pharmacologists convened in a special workshop to study the topic of pharmacology in pediatric oncology. A target of this workshop used to be to seasoned­ duce a ebook which might evaluate this subject and current it in a layout worthy for the clinician. during this e-book simple ideas of pharmacology, mechanisms of drug resis­ tance, new tools of drug supply, guidance for learning new brokers in young children, new organic reaction modifiers and the pharmacology of the main widely used chemotherapeutic brokers in kids are reviewed intensive. specific emphasis is given to discussing these subject matters which targeted­ ly practice to using antineoplastic brokers in kids with melanoma. The Editors VII Contents Preface . v Contents Vll checklist of significant individuals Xl ideas of Antineoplastic treatment in young children 1. scientific pharmacokinetics for the pediatric oncologist ................ .

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